منابع مشابه
Mechanisms of noncovalent β subunit regulation of NaV channel gating
Voltage-gated Na+ (NaV) channels comprise a macromolecular complex whose components tailor channel function. Key components are the non-covalently bound β1 and β3 subunits that regulate channel gating, expression, and pharmacology. Here, we probe the molecular basis of this regulation by applying voltage clamp fluorometry to measure how the β subunits affect the conformational dynamics of the c...
متن کاملMembrane mechanics as a probe of ion-channel gating mechanisms.
The details of conformational changes undergone by transmembrane ion channels in response to stimuli, such as electric fields and membrane tension, remain controversial. We approach this problem by considering how the conformational changes impose deformations in the lipid bilayer. We focus on the role of bilayer deformations in the context of voltage-gated channels because we hypothesize that ...
متن کاملChannel Gating
Large conductance, voltageand Ca 2 -activated K (BK Ca ) channels regulate blood vessel tone, synaptic transmission, and hearing owing to dual activation by membrane depolarization and intracellular Ca 2 . Similar to an archeon Ca 2 -activated K channel, MthK, each of four subunits of BK Ca may contain two cytosolic RCK domains and eight of which may form a gating ring. The structure of the Mth...
متن کاملCapturing Ion Channel Gating
This is a golden age for ion channels: a time when chemistry, molecular biology, and electrophysiology have come together with structural biology to provide glimpses into some truly amazing membrane proteins. And yet, as usual, the answers yield more questions. Is a new structure the structure of an open channel or of a closed one? How does the voltage sensor actually move? Though providing ama...
متن کاملCftr Channel Gating
Two papers, one in this issue (Weinreich et al., 1999) and the other in the April issue of The Journal (Zelt-wanger et al., 1999), help clarify the gating mechanisms of cystic fibrosis transmembrane conductance regulator (CFTR) Cl Ϫ channels, the products of the gene found mutated in cystic fibrosis patients. CFTR is a most unusual ion channel. It is a prominent member of the ABC transporter su...
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ژورنال
عنوان ژورنال: Cell
سال: 2017
ISSN: 0092-8674
DOI: 10.1016/j.cell.2017.07.019